　　The boisterous, arrogant professor Challenger, a reputed biologist and anthropologist, dares the London Zoological Society to mount an expedition to verify his spectacular claim, without physical proof, that his previous expedition to the Amazonian basin found live dinosaurs. Apart from him and his 'socialite' counterpart, professor Summerlee, it consists of experienced discoverer Lord Roxbury, the young reporter Ed Malone -who got publicly struck down with Challenger's umbrella at his arrival- and Jennifer Holmes, Malone's news agency's boss's daughter, essentially as conditions for putting up the money. In Brazil they are joined by Jennifer's brother David and local 'guide' Manuel Gomez. They soon discover the dinosaurs are real and dangerous, like giant spiders, but loose their helicopter and thus are desperate for a way down from the isolated plateau. They learn Roxbury knew about the fate of Burton White, an explorer whose diary they find, thus presume to be dead, in search of diamonds, and confirmation of the local tribe being the lethal guardians of the plateau's secrets, but also get surprising help...

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　　西雅圖發(fā)生一宗商店殺人案，曾被告謀殺親妻的法醫(yī)大衛(wèi)前往勘驗。無意中卻在兇案現(xiàn)場發(fā)現(xiàn)與妻子遭謀害時的相同線索，于是他決定展開調(diào)查。然而調(diào)查工作始終毫無展獲，直到他在募款晚會中結識一位美麗的神經(jīng)學教授瑪莎。瑪莎正研究某種特殊配方藥劑，可將老鼠的記憶力進行移植。這使得大衛(wèi)突發(fā)其想，偷走藥劑并將死者的記憶力注入自己體內(nèi)進行人體試驗，好一睹兇案經(jīng)過，找出兇嫌破案。　　就在大衛(wèi)一心想幫助警方破案的同時，兇嫌卻在與警方對峙時中槍身亡。失去唯一線索的大衛(wèi)，只能借用已死兇嫌的記憶找出下一步線索。原以為到此即將結束的兇案及往日冤屈，卻在大衛(wèi)親身體驗已死兇嫌的記憶過程中全面翻轉。他發(fā)現(xiàn)了攸關自身的天大謊言…

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